氧化应激在年龄相关性黄斑变性中的研究进展

任萍 吴(中国人民解放军南部战区总医院，中国)
亦笑 雷(中国人民解放军南部战区总医院，中国)
刚 陈(中国人民解放军南部战区总医院，中国)
秀兰 邹(中国人民解放军南部战区总医院，中国)
京霞 陈(中国人民解放军南部战区总医院，中国)
亮红 彭(中国人民解放军南部战区总医院，中国)

摘要

年龄相关性黄斑变性（age-related macular degeneration，AMD）是常见的全球致盲的主要原因之一。年龄相关性黄斑变性 的确切机制仍不明确，其发生发展受多种因素的影响。目前的研究表明氧化应激在年龄相关性黄斑变性的发生发展中起到 重要作用。论文对近年来氧化应激在年龄相关性黄斑变性中的相关研究进展进行综述。

关键词

年龄相关性黄斑变性；氧化应激；衰老

参考

ZEKAVAT S M, SEKIMITSU S, YE Y, et al. Photoreceptor

Layer Thinning Is an Early Biomarker for Age-Related Macular

Degeneration: Epidemiologic and Genetic Evidence from UK

Biobank OCT Data[J]. Ophthalmology, 2022,129(6):694-707.

WONG W L, SU X, LI X, et al. Global prevalence of age-related

macular degeneration and disease burden projection for 2020

and 2040: a systematic review and meta-analysis [J]. The Lancet

Global health,2014,2(2):e106-e116.

LI C, ZHU B, ZHANG J, et al. Epidemiology, health policy and

public health implications of visual impairment and age-related

eye diseases in mainland China [J]. Frontiers in public health,

,10:966006.

V U J O S E V I C S , A L O V I S I C , C H A K R AVA RT H Y U .

Epidemiology of geographic atrophy and its precursor features of

intermediate age-related macular degeneration [J]. Acta ophthalmo

logica,2023,101(8):839-856.

SPAIDE R F, JAFFE G J, SARRAF D, et al. Consensus

Nomenclature for Reporting Neovascular Age-Related Macular

Degeneration Data: Consensus on Neovascular Age-Related

Macular Degeneration Nomenclature Study Group [J]. Ophthalmol

ogy,2020,127(5):616-636.

SIES H. Oxidative stress: a concept in redox biology and medicine

[J]. Redox biology, 2015,4:180-183.

RUAN Y, JIANG S, GERICKE A. Age-Related Macular

Degeneration: Role of Oxidative Stress and Blood Vessels [J].

International journal of molecular sciences,2021,22(3).

KUSHWAH N, BORA K, MAURYA M, et al. Oxidative Stress

and Antioxidants in Age-Related Macular Degeneration [J].

Antioxidants (Basel, Switzerland),2023,12(7).

DENG Y, QIAO L, DU M, et al. Age-related macular degeneration:

Epidemiology, genetics, pathophysiology, diagnosis, and targeted

therapy [J]. Genes & diseases,2022,9(1):62-79.

BELLEZZA I. Oxidative Stress in Age-Related Macular

Degeneration: Nrf2 as Therapeutic Target [J]. Frontiers in

pharmacology,2018,9:1280.

FANG Y, TAUBITZ T, TSCHULAKOW A V, et al. Removal of RPE

lipofuscin results in rescue from retinal degeneration in a mouse model

of advanced Stargardt disease: Role of reactive oxygen species [J].

Free radical biology & medicine,2022,182:132-149.

ZHU D, WU J, SPEE C, et al. BMP4 mediates oxidative

stress-induced retinal pigment epithelial cell senescence and is

overexpressed in age-related macular degeneration [J]. The Journal

of biological chemistry,2009,284(14):9529-9539.

GUYMER R H, CAMPBELL T G. Age-related macular degeneration

[J]. Lancet (London, England),2023,401(10386):1459-1472.

SPARROW J R, HICKS D, HAMEL C P. The retinal pigment

epithelium in health and disease [J]. Current molecular medicine,

,10(9):802-823.

CHAN T C, WILKINSON BERKA J L, DELIYANTI D, et al. The

role of reactive oxygen species in the pathogenesis and treatment of

retinal diseases [J]. Experimental eye research,2020,201:108255.

LEE K S, LIN S, COPLAND D A, et al. Cellular senescence

in the aging retina and developments of senotherapies for agerelated macular degeneration [J]. Journal of neuroinflammati

on,2021,18(1):32.

ARMENTO A, HONISCH S, PANAGIOTAKOPOULOU V, et

al. Loss of Complement Factor H impairs antioxidant capacity

and energy metabolism of human RPE cells [J]. Scientific

reports,2020,10(1):10320.

TERLUK M R, KAPPHAHN R J, SOUKUP L M, et al.

Investigating mitochondria as a target for treating age-related

macular degeneration [J]. The Journal of neuroscience : the official

journal of the Society for Neuroscience,2015,35(18):7304-7311.

KAARNIRANTA K, UUSITALO H, BLASIAK J, et al.

Mechanisms of mitochondrial dysfunction and their impact on

age-related macular degeneration [J]. Progress in retinal and eye

research,2020,79:100858.

LU L, GU X, HONG L, et al. Synthesis and structural

characterization of carboxyethylpyrrole-modified proteins:

mediators of age-related macular degeneration [J]. Bioorganic &

medicinal chemistry,2009,17(21):7548-7561.

SHEN J K, DONG A, HACKETT S F, et al. Oxidative damage in

age-related macular degeneration [J]. Histology and histopathology,

,22(12):1301-1308.

CHEW E Y, CLEMONS T E, AGRóN E, et al. Long-term

effects of vitamins C and E, β-carotene, and zinc on age-related

macular degeneration: AREDS report no. 35 [J]. Ophthalmolo

gy,2013,120(8):1604-1614.

EVANS J R, LAWRENSON J G. Antioxidant vitamin and

mineral supplements for slowing the progression of age-related

macular degeneration [J]. The Cochrane database of systematic

reviews,2023,9(9):Cd000254.

JEFFREY B G, NEURINGER M. Age-related decline in rodphototransduction sensitivity in rhesus monkeys fed an n-3 fatty

acid-deficient diet [J]. Investigative ophthalmology & visual

science,2009,50(9):4360-4367.

MCGILL T J, RENNER L M, NEURINGER M. Elevated Fundus

Autofluorescence in Monkeys Deficient in Lutein, Zeaxanthin, and

Omega-3 Fatty Acids [J]. Investigative ophthalmology & visual

science,2016,57(3):1361-1369.

KAARNIRANTA K, BLASIAK J, LITON P, et al. Autophagy in agerelated macular degeneration [J]. Autophagy, 2023,19(2):388-400.

LIU S, PI J, ZHANG Q. Signal amplification in the KEAP1-

NRF2-ARE antioxidant response pathway [J]. Redox biology,

,54:102389.

HENNING Y, BLIND U S, LARAFA S, et al. Hypoxia aggravates

ferroptosis in RPE cells by promoting the Fenton reaction [J]. Cell

death & disease,2022,13(7):662.

WANG K, ZHENG M, LESTER K L, et al. Light-induced Nrf2(-

/-) mice as atrophic age-related macular degeneration model and

treatment with nanoceria laden injectable hydrogel [J]. Scientific

reports,2019,9(1):14573.

BLASIAK J, KOSKELA A, PAWLOWSKA E, et al. EpithelialMesenchymal Transition and Senescence in the Retinal Pigment

Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice [J].

International journal of molecular sciences,2021,22(4).

JUSTILIEN V, PANG J J, RENGANATHAN K, et al. SOD2

knockdown mouse model of early AMD [J]. Investigative

ophthalmology & visual science,2007,48(10):4407-4420.

CHOUDHARY M, DING J D, QI X, et al. PPARβ/δ selectively

regulates phenotypic features of age-related macular degeneration

[J]. Aging, 2016,8(9):1952-1978.

FUJIHARA M, NAGAI N, SUSSAN T E, et al. Chronic cigarette

smoke causes oxidative damage and apoptosis to retinal pigmented

epithelial cells in mice [J]. PloS one,2008,3(9):e3119.

WANG L, YU X, ZHANG D, et al. Long-term blue light

exposure impairs mitochondrial dynamics in the retina in lightinduced retinal degeneration in vivo and in vitro [J]. Journal of

photochemistry and photobiology B, Biology,2023,240:112654.

HOLLYFIELD J G, BONILHA V L, RAYBORN M E, et al.

Oxidative damage-induced inflammation initiates age-related

macular degeneration [J]. Nature medicine,2008,14(2):194-198.

BHARTI K, DEN HOLLANDER A I, LAKKARAJU A, et al.

Cell culture models to study retinal pigment epithelium-related

pathogenesis in age-related macular degeneration [J]. Experimental

eye research,2022,222:109170.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i5.17770