微卫星不稳定在结直肠癌的应用及研究进展

帅 黄(同济医学院附属武汉市中心医院，中国)
寒松 杜(同济医学院附属武汉市中心医院，中国)

摘要

结直肠癌（CRC）在中国发病率第三，仅次于肺癌和乳腺癌，是最常见的消化道恶性肿瘤之一。目前研究发现了三种基因组 不稳定方式引起分子致癌，包括染色体不稳定性（CIN），微卫星不稳定性（MSI），CpG岛甲基化表型（CIMP）。其中微 卫星不稳定与错配修复（MMR）基因密切相关。MSI作为结肠癌最早且最为重要的分子标记物之一，对结肠癌的诊断、病理 特征、预后评估、治疗手段选择具有重要意义。因此，论文就微卫星不稳定在结肠癌的应用及研究进展做简要综述。

关键词

微卫星不稳定；结肠癌；综述

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i5.17774