EZH2 与肿瘤细胞初级纤毛发生的研究进展

斐斐 余(兰州大学生命科学学院，中国)
岚 高(兰州大学生命科学学院，中国)

摘要

Zeste基因增强子同源物2（enhancer of Zeste homolog 2，EZH2）是一种重要的甲基转移酶，是PGCs基因家族的重要成员之一。EZH2作为核心催化亚基参与构成多梳抑制复合物2，以调控转录活性的方式参与肿瘤的发生与发展。初级纤毛作为一种以微管为基础的细胞器，其结构和功能的异常往往也会影响肿瘤细胞的增殖，侵袭与治疗敏感性。论文通过阐述两者分别在肿瘤发生发展中的作用，进一步探讨二者在肿瘤的发生发展中是否存在联合作用，以及为肿瘤的靶向治疗提供一定参考依据。

关键词

EZH2；初级纤毛；肿瘤治疗

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i6.18554