维生素D代谢与肿瘤关系的研究进展

蔚 高(解放军总医院肝胆外二科，中国 航天中心医院肝胆外科，中国)
荣 刘(解放军总医院肝胆外二科，中国)

摘要

恶性肿瘤是当前严重威胁人类生命的疾病，并且人们对于绝大多数恶性肿瘤的认识仍然不识其“庐山真面目”, 对于恶性肿瘤的发生、发展机制没有确切的认识，那么对于其诊断、治疗就更加缺乏行之有效的手段。维生素作为一种外源性物质，需要人体通过食物中摄取，来满足细胞功能的正常进行，在维持机体正常运转过程中的作用不可替代。近年来，维生素在恶性肿瘤性疾病中的作用，引起人们重视 。维生素 D（VD）作为唯一一种人体可少量自身合成的维生素，被认为是一种类固醇，其作用较其他维生素更加受到关注，普遍认同的是其在维持骨质稳定，调节钙质吸收代谢方面的作用。活化的 VD-1， 25（OH）2D3 可调节体内钙磷水平，维持骨质正常功能，其在肿瘤中的作用，近年来愈发受到关注。目前，认为 1， 25（OH） 2D3 具有抗肿瘤作用。VD 在体内的活化及失活是经过一系列细胞色素酶催化进行，而 CYP24A1 是活性 VD 降解失活的关键基因。下面笔者将对 VD 代谢系统、尤其 CYP24A1 基因，与肿瘤相关研究，以及对于CYP24A1 表达调控的相关研究进展进行综述。

关键词

维生素 D；癌症；CYP24A1

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v2i3.1921