MicroRNA 在变应性鼻炎中的研究进展

子 徐(承德医学院附属医院，中国)
祎(承德医学院附属医院，中国)

摘要

变应性鼻炎（Allergic rhinitis，AR）是免疫球蛋白E（immunoglobulin E，IgE）介导的鼻部相关的非感染性慢性炎性疾病，主要表现为阵发性喷嚏、流清涕、鼻塞，可导致睡眠障碍、注意力下降、疲劳甚至是抑郁，从不同程度上影响人们的生活质量和工作效率，目前对于AR的治疗已取得极大进展，但仍有部分患者的症状未得到足够改善。因此，有必要更加深入研究AR发病机制从而进一步提升AR的诊疗水平。MicroRNA（miRNA）是一类短单链非编码RNA，通过结合靶信使RNA（mRNA）上的3’-末端翻译位点诱导RNA降解或阻断蛋白质合成，可以调节转录后基因的表达，被认为与许多炎性疾病、血管疾病、癌症等相关，是众多国内外学者的研究重点。论文与AR密切相关的miRNA研究进展作一简述，希望可以对AR诊断与治疗方面的研究进展提供帮助。

关键词

变应性鼻炎；miRNA；诊断治疗

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i7.19719