鲍曼不动杆菌耐药机制的研究进展

桂花 戴(武冈市人民医院，中国)
贻海 姜(武冈市人民医院，中国)
云 彭(武冈市人民医院，中国)

摘要

鲍曼不动杆菌（Acinetobacter baumannii，AB）为不动杆菌属中最常见的，在水、土壤、医院环境及人体与外界相通的系统中普遍存在，为医院的重要致病菌之一。近年来此菌感染在增加，且其耐药性也与日俱增，耐碳青霉烯类的鲍曼不动杆菌在中国发展很快，近来又发现“全耐药”鲍曼不动杆菌，目前鲍曼不动杆菌被中国定为最重要的“超级细菌” 。因此，本文将对鲍曼不动杆菌的耐药机制进行概述。鲍曼不动杆菌耐药机制较复杂，主要包括产抗菌药物灭活酶、外排系统的高表达、膜孔蛋白的缺失、药物作用靶位的变化、整合子、质粒、转座子、形成细菌生物膜和亚致死剂量的抗病原微生物药物诱导等。

关键词

鲍曼不动杆菌；金属酶；整合酶；外排泵

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v2i3.1998