绝经后女性甘油三酯 - 葡萄糖体质指数与冠状动脉病变程度的关系

剑楠 马(承德医学院研究生学院，中国;保定市第一中心医院心内科，中国;)
杰 陶(保定市第一中心医院心内科，中国;)
大森 桑(保定市第一中心医院心内科，中国;)
华 李(保定市第一中心医院心内科，中国;)
旗 张(保定市第一中心医院心内科，中国;)

摘要

目的：探索绝经后女性甘油三酯葡萄糖体质指数（TyG-BMI）和冠状动脉病变程度的关系。方法：选择2022年10月1日—2024年3月1日期间就诊于保定市第一中心医院心血管内科的绝经后女性158例作为观察对象，根据Gensini评分结果分为低、中、高狭窄。行logistic回归分析探讨绝经后女性冠状动脉高狭窄的影响因素并绘制受试者工作特征（ROC）曲线评估TyG-BMI对冠状动脉高狭窄的预测价值。结果：①高狭窄的TyG-BMI高于低和中狭窄（P＜0.05）。②单、多因素logistic回归分析均显示TyG-BMI是绝经后女性冠状动脉高狭窄的独立危险因素。③TyG-BMI预测冠状动脉高狭窄的ROC曲线下面积为0.763（95%CI：0.681~0.845，P＜0.001）。结论：TyG-BMI可以作为绝经后女性冠状动脉病变程度的预测因子。

关键词

绝经后女性；甘油三酯葡萄糖体质指数；冠状动脉病变程度

参考

刘华,陈子平,刘奕然.血尿酸、血清同型半胱氨酸与冠状动脉病变程度的关系分析[J].中国老年保健医学,2020,18(2):22-24.

Sousa N F S, Lima M G, Cesar C L G, et al. Active aging: prevalence and gender and age differences in a population-based study.Cad Saúde Pública 2018;34(11):e00173317[J]. Cadernos de saude publica,2019,35(2):eER173317.

Gurevitz O, Jonas M, Boyko V, et al. Clinical profile and long-term prognosis of women ≤50 years of age referred for coronary angiography for evaluation of chest pain[J].The American Journal of Cardiology,2000,85(7):806-809.

Yu Z, Ruiling W, Xuelian F, et al. Non-insulin-based insulin resistance indexes in predicting severity for coronary artery disease[J].Diabetology & metabolic syndrome, 2022,14(1):191.

Ranganath M, Sihoon L, Hui C, et al. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage[J].American journal of physiology. Endocrinology and metabolism,2008,294(1):E15-26.

Jing L, HaiW, Zhen D, et al. The Association of Triglyceride Glucose index for Coronary Artery Disease in Postmenopausal Women[J]. Clinical and applied thrombosis/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2022,28:10760296221094030.

Lim J, Kim J, Koo S H, et al. Comparison of triglyceride glucose index, and related parameters to predict insulin resistance in Korean adults: an analysis of the 2007–2010 Korean national health and nutrition examination survey[J]. PLoS ONE, 2019,14(3):e0212963.

Yang X, Li K, Wen J, et al. Association of the triglyceride glucose-body mass index with the extent of coronary artery disease in patients with acute coronary syndromes[J]. Cardiovascular diabetology, 2024,23(1):24.

Nansseu Jobert Richie N, Moor Vicky Jocelyne Ama, et al. Atherogenic index of plasma and risk of cardiovascular disease among Cameroonian postmenopausal women[J]. Lipids in health and disease, 2016,15(1):49.

Martínez Sánchez F, Vargas Abonce V, Guerrero Castillo A, et al. Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes[J]. Primary care diabetes, 2020,15(2):293-299.

Antonino P D, et al. .Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents[J]. Endocrine reviews,2019,40(6):1447-1467.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i8.20487