BTG3 在结直肠癌中的临床病理学和预后意义

东辉 任(承德医学院附属医院肿瘤科，中国)
仁祥 刘(承德医学院附属医院肿瘤科，中国)
华川 郑(承德医学院附属医院肿瘤科，中国)

摘要

B细胞转位基因3（BTG3）是一种抑癌基因，对调节细胞分化、细胞周期及抑制癌细胞无限增殖等具有重要作用。BTG3属于B细胞迁移基因/ErbB2转录因子家族（BTG/Tob），其N端通过结合E2F1蛋白，阻碍DP1和E2F1转录因子结合DNA，进而使DNA合成受阻。在这项研究中，我们使用GEO数据库、TCGA数据库、仙桃、UALCAN数据库和Kaplan-Meier绘图仪数据库等对BTG3表达进行了免疫组化及生物信息学分析。结果显示与正常组织相比，BTG3在结直肠癌表达升高而甲基化降低。BTG3的表达直接或间接地影响免疫细胞与肿瘤细胞之间的相互作用。BTG3相关基因在功能上可能存在协同作用或者处于同一调控通路，从而为癌症的发生、发展提供研究线。因此，BTG3的表达有可能作为反映结直肠癌症发生、发展、侵袭和预后的潜在标志物。

关键词

BTG3；结直肠癌；免疫组化；生信分析

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i10.21643