冻融胚胎移植周期使用己酮可可碱治疗结局研究

秀芹 孙(济宁市第一人民医院生殖医学科，中国)
考考 赵(济宁市第一人民医院生殖医学科，中国)

摘要

目的：探讨子宫内膜偏薄患者冻融胚胎移植(frozen-thawed embryo transfer，FET)周期使用己酮可可碱治疗的临床效果。方法：回顾性分析2019 年1月至2021年6月于我院进行FET的子宫内膜偏薄患者60例，其中对照组38例，己酮可可碱组22例，比较两组间着床率、临床妊娠率及早期自然流产率差异。结果：两组间着床率、临床妊娠率无显著差异，己酮可可碱组早期自然流产率较对照组显著降低（P=0.046）。结论：子宫内膜偏薄的患者FET周期使用己酮可可碱治疗可降低早期自然流产率。

关键词

子宫内膜；己酮可可碱；冻融胚胎移植；早期自然流产

参考

De Neubourg D, Peeraer K, Debrock S, et al. Belgium Model of Coupling Reimbursement of ART Costs to Restriction in Number of Embryos Transferred[J]. BMJ,2014,348:g1559.

Jian-Chun Li, Yan-Hong Wang, li-Ying Peng, et al. A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial.

Krief F, Simon C, Goldstein R, et al. Efficacy of tocopherol and pentoxifylline combined therapy for women undergoing assisted reproductive treatment with poor endometrial development: a retrospective cohort study on 143 patients[J]. Human fertility Cambridge, England,2019:1-9.

Kasius A, Smit JG, Torrance HL, et al. Endometrial thickness and pregnancy rates after IVF: a systematic review and meta-analysis[J]. Hum Reprod Update, 2014, 20(4):530-541.

FAN X, KRIEG S, KUOC J, et al. VEGF blockade inhibits angiogenesis and reepithelialization of endometriums[J]. The FASEBJournal,2008,22(10):3571-3580.

Casper RF. It’s time to pay attention to the endometrium[J]. Fertil Steril, 2011,96(3):519-521.

Huang PT, Chen SU, Chao KH, et al. Effects of fertilization promoting peptide, adenosine, and pen toxifylline on thawed human sperm[J]. Arch Androl, 2003,49(2):145-153.

Halme J, Becker S, Wing R. Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis [J]. American Journal of Obstetrics and Gynecology,1984,148(1):85-90.

Steinleitner A, Lambert H, Roy S. Immunomodulation with pentoxifylline abrogates macrophage-mediated infertility in an in vivo model: a paradigm for a novel approach to the treatment of endometriosis associated subfertility[J]. Fertility and Sterility,1991,55(1):26-31.

ACHARYA S, YASMIN E, BALEN AH. et al. The use of a combination of pentoxifylline and tocopherol in women with a thin endometrium undergoing assisted conception therapies: a report of 20 cases[J]. Hum Fertil, 2009,12(4):198-203.

Ledee-Bataille N, Olivennes F, LefaixJ L, et al. Combined treatment by pentoxifylline and tocopherol for recipient women with a Thin endometrium enrolled in an oocyte donatin programme[J]. Hum Reprod, 2002, 17(5):1249-1253.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i10.21680