多种代谢参数与 GDF15 分泌调节之间的关系研究进展

梓璐 任(承德医学院研究生院，中国;)
建凤 刘(沧州市人民医院，中国;)

摘要

生长分化因子15（growth differentiation factor-15，GDF15），GDF15是一种应激反应性细胞因子，对生物的健康和寿命有着重要影响。尽管GDF15在20多年前就被认定出来，但其功能仍然很复杂，尚未完全阐明。GDF15已被认为通过GDNF家族受体a样（GFRAL）受体调节啮齿动物的食物摄入和胰岛素敏感性，在怀孕和许多疾病状态下会升高，但具体分泌调节有待进一步研究，本综述讨论了多种代谢参数与GDF15水平调节之间的关系。

关键词

生长分化因子15；循环水平；生物标志物；炎症；代谢

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i11.22429