白脂素在结直肠癌中的研究进展

森 王(承德医学院，中国;)
继攀 刘(衡水市人民医院，中国;)

摘要

结直肠癌(colorectal cancer)是全球第三大常见的癌症,也是死亡率居第二位的癌症。随着我国居民膳食结构和生活习惯的变化,国内结直肠癌发病率呈上升趋势。由于高脂饮食和缺乏运动的生活习惯引起的体重增加，似乎和结直肠癌的发生有着密切关系。肥胖通过复杂的途径促进结直肠癌的发生发展，导致结直肠癌的死亡率更高。白脂素通过激活下丘脑的促食神经元以及抑制厌食神经元，以此刺激食欲和加重肥胖。因此，本文系统综述白脂素的生物学功能及其在结直肠癌中的分子机制和影响。

关键词

白脂素；结直肠癌；肥胖；诊断标志物

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i3.24745