热休克蛋白 90（HSP90）在治疗骨质疏松中的研究进展

文娟 张(宁波大学附属第一医院药学部，中国)

摘要

热休克蛋白90（HSP90）作为一种重要的分子伴侣，在细胞的应激反应及维持蛋白质稳态中发挥着关键作用。近年来的研究表明，HSP90不仅参与了细胞应激反应的调节，还对骨代谢、骨形成及骨吸收过程产生显著影响，逐渐引起了学术界的广泛关注。尽管已有多项研究探讨了HSP90在骨质疏松中的作用，但其具体机制仍然不详，临床应用仍存在诸多未解之谜。本文旨在综述HSP90在抗骨质疏松方面的研究进展，深入探讨其潜在的作用机制以及未来的临床应用前景。相关研究表明，HSP90可能通过调节关键的信号通路和转录因子，促进骨矿化并抑制骨吸收，从而为骨质疏松的治疗提供了新的方向和思路。

关键词

热休克蛋白90，骨质疏松，骨代谢，药物作用机制

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i4.25544