细胞衰老与衰老相关疾病研究进展

潇雨 田(中国药科大学，中国)
娜 卢(中国药科大学，中国)

摘要

衰老（Senescence）是细胞功能逐渐退化的一种状态，在这种状态下细胞几乎丧失复制能力，并且细胞周期抑制基因p16INK4a 的表达升高。细胞衰老贯穿生物个体的整个生命过程，在各种生理以及病理过程中发挥重要的作用。一方面，衰老的细胞能够促进胚胎发育，伤口愈合和宿主免疫反应以及抑制肿瘤发生发展等。另一方面，随着年龄增长而在体内积累的衰老细胞也会对机体带来有害的影响。这些不能增殖的细胞产生衰老相关分泌表型（Senescence-Associated Secretory Phenotype,SASP），促进衰老相关疾病（Aging-related Disease）的发生发展，而清除衰老细胞能够减缓衰老相关疾病的症状。因此寻找能够特异性杀死衰老细胞的药物 （Senolytics）成为了抗衰老领域的研究重点。

关键词

细胞衰老；衰老相关分泌表型；衰老相关疾病；抗衰老；Senolytics

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v2i5.2583