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细胞衰老与衰老相关疾病研究进展

潇雨 田(中国药科大学,中国)
娜 卢(中国药科大学,中国)

摘要

衰老(Senescence)是细胞功能逐渐退化的一种状态,在这种状态下细胞几乎丧失复制能力,并且细胞周期抑制基因p16INK4a 的表达升高。细胞衰老贯穿生物个体的整个生命过程,在各种生理以及病理过程中发挥重要的作用。一方面,衰老的细胞能够促进胚胎发育,伤口愈合和宿主免疫反应以及抑制肿瘤发生发展等。另一方面,随着年龄增长而在体内积累的衰老细胞也会对机体带来有害的影响。这些不能增殖的细胞产生衰老相关分泌表型(Senescence-Associated Secretory Phenotype,SASP),促进衰老相关疾病(Aging-related Disease)的发生发展,而清除衰老细胞能够减缓衰老相关疾病的症状。因此寻找能够特异性杀死衰老细胞的药物 (Senolytics)成为了抗衰老领域的研究重点。

关键词

细胞衰老;衰老相关分泌表型;衰老相关疾病;抗衰老;Senolytics

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参考

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v2i5.2583

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