NLR、Fib 在 2 型糖尿病肾病中的研究进展综述

萍 陈(昆明市第一人民医院肾内科，中国;)
曦 张(昆明市第一人民医院肾内科，中国;)
娅 李(昆明市第一人民医院呼吸科中国;)

摘要

糖尿病肾病是 2 型糖尿病的常见并发症，具有显著的全球公共卫生意义。研究表明，炎症在糖尿病肾病的发病和进展中起关键作用。NLR 和 Fib 作为炎症标志物，与糖尿病肾病的发生和进展密切相关。NLR通过反应促炎性中性粒细胞与抗炎性淋巴细胞的不平衡，在预测早期 2 型糖尿病肾病及其进展中显示出重要价值。Fib 通过促进慢性炎症和组织纤维化，与肾功能恶化和终末期肾病的发生密切相关。两者的联合应用（F-NLR 评分）显著提高了对 2 型糖尿病肾病病程评估和风险预测的敏感性与特异性。未来通过多中心研究和机制探索，NLR 与 Fib 在 2 型糖尿病肾病早期诊断、风险分层和个性化治疗中的临床应用有望进一步优化。

关键词

糖尿病肾病；中性粒细胞与淋巴细胞比值；纤维蛋白原；炎症

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i5.27039