ISG15 在下咽癌中表达的生物信息学分析

颖杰 王(承德医学院，中国;)
连贺 李(中国医科大学朝阳市中心医院，中国;)
良玉 邹(中国医科大学朝阳市中心医院，中国;)

摘要

通过对ISG15进行相关生物信息学分析，首先通过TCGA数据库泛癌分析其在癌症组织中表达情况，发现其在多种癌种中表达上调，其中在头颈癌中显著上调，确认其为癌症相关基因，经TCGA数据库差异分析下咽癌以及正常组织中表达，发现相比正常组织，ISG15在下咽癌中表达显著升高，通过富集分析其在下咽癌中可能发挥的作用，进一步认为 ISG15在下咽癌发生中发挥一定作用。最后经qPCR实验结果证实：ISG15在下咽癌中表达上调，有成为下咽癌分子标志物的潜力。

关键词

ISG15生物信息学；下咽癌；GSEA富集分析；qPCR

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i5.27052