粪便样本中 DNA 甲基化生物标志物在结直肠癌筛查中的进展

家杰 魏(承德医学院，中国;保定市第一中心医院，中国;)
惠卿 张(保定市第一中心医院，中国;)

摘要

结直肠癌（Colorectal Cancer, CRC）是癌症相关死亡的主要原因之一，每年导致数百万患者丧生，给公共卫生系统带来沉重负担。尽管现有的筛查方法如粪便潜血试验（FIT）、结肠镜检查等在一定程度上降低了CRC的死亡率，但其局限性促使研究者探索更有效的筛查手段。近年来，基于粪便DNA甲基化生物标志物的检测技术因其非侵入性、高敏感性和特异性而备受关注。本文综述了DNA甲基化生物标志物在CRC筛查中的研究进展，比较了其与传统筛查方法的优劣，并探讨了未来发展方向。

关键词

结直肠癌；DNA甲基化；粪便检测；早期诊断；表观遗传学

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i8.30654