PRDX1、HDAC6 与脑小血管病性认知障碍相关性的研究进展

远帆 谷(承德医学院附属医院神经内科，中国·河北 承德 067000)
亮 赵(承德医学院附属医院神经内科，中国·河北 承德 067000)

摘要

脑小血管病（Cerebral Small Vessel Disease，CSVD）是导致血管性认知障碍和痴呆的主要病因之一，其早期诊断困难，缺乏有效治疗手段。本文综述了血清过氧化物氧化还原蛋白1（PRDX1）和组蛋白去乙酰化酶6（HDAC6）在CSVD相关认知障碍（CSVD-CI）中的作用及其机制。PRDX1作为重要的抗氧化蛋白，通过清除活性氧氮物种、减轻氧化应激、保护血脑屏障完整性以及抑制细胞凋亡等途径，在CSVD发生发展中发挥保护作用。HDAC6作为表观调控关键因子，参与突触功能、线粒体运输及蛋白质聚集清除等过程，其异常表达或核转位可影响脑源性神经营养因子表达与突触可塑性，进而加剧认知功能损害。研究表明，PRDX1和HDAC6在CSVD-CI的发病机制中具有重要地位，可能成为早期诊断和治疗的潜在生物标志物与干预靶点。未来研究应进一步探索其在临床转化中的应用前景。

关键词

脑小血管病（CSVD）；认知障碍（CI）；PRDX1；HDAC6；

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i11.34567