铁死亡在结直肠癌中的研究进展

紫楠 朱(承德医学院附属医院，中国)
佩剑 丁(承德医学院附属医院，中国)

摘要

铁死亡作为一种独特的铁依赖性脂质过氧化驱动的程序性细胞死亡方式，近年来在肿瘤研究领域展现出重要的生物学意义。结直肠癌作为全球范围内发病率和死亡率均较高的恶性肿瘤，其复杂的发生发展机制仍需深入研究。当前研究表明，铁死亡相关基因在结直肠癌的发生、进展及预后中扮演关键角色，但其具体调控机制尚未完全明确。本文基于最新的生物信息学工具和多组学数据，系统分析了铁死亡相关基因的表达特征、功能富集及信号通路，进一步探讨了这些基因与肿瘤免疫微环境的相互作用。综述旨在揭示铁死亡相关基因在结直肠癌中的潜在分子机制，为未来精准诊断和靶向治疗提供理论支持和新思路，推动该领域的基础与临床研究发展。

关键词

铁死亡，结直肠癌，生物信息学，基因表达，免疫微环境

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v9i2.36522