莱菔硫烷对2型糖尿病认知功能障碍的调控作用研究进展

强 刘(华北理工大学附属唐山市工人医院内分泌二科，中国)
辉 房(唐山市工人医院，中国·河北 唐山 063000)
啸啸 王(河北医科大学，中国)
莹 杨(河北医科大学，中国)
嘉琦 刘(华北理工大学附属唐山市工人医院内分泌二科，中国)
翔宇 薛(华北理工大学附属唐山市工人医院内分泌二科，中国)

摘要

论文通过再述有关莱菔硫烷（SFN）对不同疾病的体内和体外模型的有益作用的最新证据，讨论了 SFN 在氧化应激、炎症和代谢中具有很强的生物活性，经过论文讨论发现莱菔硫烷是一种重要的抗氧化物质。大量实验研究表明 SFN 作为 Nrf2 通路的诱导剂，可以通过上调 Nrf2 及其下游基因的表达来发挥抗氧化作用。莱菔硫烷对于糖尿病认识功能的治疗具有很大的药用价值，为以后的临床治疗提供了一种新思路。　

关键词

莱菔硫烷；糖尿认知功能障碍；Nrf2

参考

Shokeir, A.A., et al., Activation of Nrf2 by Ischemic Preconditioning and Sulforaphane in Renal Ischemia/Reperfusion Injury: aComparative Experimental Study, 2014(03):313.

Yang, N., et al., Caffeic acid phenethyl ester up-regulates antioxidant levels in hepatic stellate cell line T6 via an Nrf2-mediatedmitogen activated protein kinases pathway. World J Gastroenterol,2017(07):1203-1214.

Yagishita, Y., et al., Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress. Cell Reports, 2017(08):2030-2044.

Ma, Q., Transcriptional responses to oxidative stress: Pathological and toxicological implications. Pharmacology & Therapeutics,

(03):376-393.

Balaban, R.S., S. Nemoto, and T. Finkel, Mitochondria, Oxidants, and Aging. Cell 2005(04):483-495.

Kensler, T.W., N. Wakabayashi, and S. Biswal, Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE

Pathway. Annu Rev Pharmacol Toxicol, 2007(01):89-116.

Lan, A., et al., Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the

isothiocyanate moiety. 2016(33):53502-53514.

Cheignon, C., et al., Oxidative stress and the amyloid beta peptide in Alzheimer’s disease. Redox Biol, 2018(14):450-464.

Gubitosi-Klug and R. A., The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications

Study at 30 Years: Summary and Future Directions: Figure 1. Diabetes Care, 2014(01):44-49.

Lee, J., et al., Untimely Oxidative Stress in β-cells Leads to Diabetes- Role of Circadian Clock in β-cell Function. Free Radic Biol Med, 2018.

白桂荣 . 肥胖合并 2 型糖尿病患者游离脂肪酸、同型半胱氨酸的水平及其临床意义 [J]. 宁夏医学杂志 ,2019(09):117.

Sanders, F.W.B. and J.L. Griffin, De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. Biological Reviews, 2016.

Yang, Q., V. Archana, and K.B. B., Metabolites as regulators of insulin sensitivity and metabolism. Nature Reviews Molecular CellBiology, 2018.

Shimobayashi, M., et al., Insulin resistance causes inflammation in adipose tissue. 2018.

Feillet-Coudray, C., et al., Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/HighFructose Diet. Lipids, 2019(01):332.

刘颖 , 傅晗 , 师腾瑞 . 高脂饲料喂饲 C57 小鼠诱发胰岛素抵抗过程中肝脏氧化应激水平及 Nrf2、NRF-1 和 mtTFA 蛋白表达的变化 . 癌变·畸变·突变 ,2015(03):196.

Carru, C., et al., Associations between markers of oxidative stress, skeletal muscle mass and function and to the influence of resistance exercise training, in older adults. Experimental Gerontology, 2018.

Carru, C., et al., Markers of oxidative stress, skeletal muscle mass and function, and their responses to resistance exercise training in older adults. Experimental Gerontology, 2018.

Kim, K. and M.P. Sang, Association of muscle mass and fat mass with insulin resistance and the prevalence of metabolic syndrome in Korean adults: a cross-sectional study. Sci Rep, 2018(01):2703.

Barazzoni, R., et al., Fatty acids acutely enhance insulin induced oxidative stress and cause insulin resistance by increasing

mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction. 2012(03):773-782.

Rigato, M., G.P. Fadini, and A. Avogaro, Diabetes and the Cardiovascular System. 2019.

易小芳 and 谭超 ,Nrf2/ARE 通路调节机制的研究进展 . 天津医药, 2015(05):131-133.

etal, I.W.K., Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. GENES & DEVELOPMENT, 1999(01):76-86.

Nezu, M., N. Suzuki, and M. Yamamoto, Targeting the KEAP1- NRF2 System to Prevent Kidney Disease Progression. American

Journal of Nephrology, 2017(06):473-483.

Itoh, K., et al., An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements. Biochemical & Biophysical Research Communications, 1997(02):0-322.

Luke, et al., Role of Nrf2 in protection against acute kidney injury. 2013.

Kong, W., et al., Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. Nephrology Dialysis Transplantation, 2017(05):5.

Montserrat, R.D.L.V., et al., NRF2-targeted therapeutics: New targetsand modes of NRF2 regulation. Curr Opin Toxicol, 2016(01):62-70.

Yamawaki, K., H. Kanda, and R. Shimazaki, Nrf2 activator for the treatment of kidney diseases. Toxicology & Applied Pharmacology, 2018.

Pu, D., et al., Protective effects of sulforaphane on cognitive impairments and AD-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity. Neuroscience, 2018.

Shah, Z.A., et al., Role of Reactive Oxygen Species in Modulation of Nrf2 following Ischemic Reperfusion Injury. Neuroscience,

(01):53-59.

Gang, C., et al., Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. Journal of Neuroscience Research, 2011.

Roberto, et al., Sulfoaphane - role in aging and neurodegeneration. Geroscience, 2019.

Geeta, N., K. Ashutosh, and S.S. S, Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic

neuropathy in rats and high glucose-induced changes. Current neurovascular research, 2011.

Zhang, H.Q., et al., Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization. Molecular Nutrition & Food Research, 2016.

Pennisi, M., et al., Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease. Journal of Neuroscience Research, 2016.

Hernandez-Rabaza, V., et al., Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in

hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.

Journal of Neuroinflammation, 2016.

Jie, G., et al., Sulforaphane alleviates lipopolysaccharide-induced spatial learning and memory dysfunction in mice: the role of BDNFmTOR signaling pathway. Neuroscience, 2018.

Jhang, K.A., et al., Sulforaphane rescues amyloid-β eptidemediated decrease in MerTK expression through its antiinflammatory effect in human THP-1 macrophages. Journal of Neuroinflammation, 2018.

Jeffrey, L., Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration? Antioxidants, 2017.

DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i2.3806