膳食萝卜硫素对代谢相关脂肪性肝病的预防与干预作用

丽 冯(无锡太湖学院健康医学院，中国;)
钰 曹(苏州苏大卫生与环境技术研究所有限公司，中国;)
子凡 朱(无锡太湖学院健康医学院，中国;)
慧如 林(无锡太湖学院健康医学院，中国;)

摘要

代谢相关脂肪性肝病（metabolic dysfunction-associated fatty liver disease, MAFLD）是全球高发的慢性肝病之一，其复杂的病理机制及缺乏有效治疗手段，成为当前临床与基础研究的焦点。目前，尚无获批用于MAFLD治疗的特异性药物。临床干预主要采用降脂和抗炎药物，但其疗效与安全性仍缺乏大规模临床证据支持。近年来，膳食来源的天然活性物质作为MAFLD防治的新策略逐渐受到关注。研究表明，植物活性成分萝卜硫素（sulforaphane, SFN）在动物模型中可减轻体重并改善胰岛素稳态，但其对MAFLD的具体作用及分子机制尚不完全明确。本文系统梳理了近年来关于膳食SFN的来源、生物活性特性及其对MAFLD的多维作用机制，包括激活Nrf2/ARE抗氧化系统、调控FGF21信号通路以及调节肠道菌群组成等方面，强调其作为功能性食品成分在MAFLD防治中的应用潜力，并为后续临床研究提供科学基础。

关键词

萝卜硫素；代谢相关脂肪性肝病；膳食；干预作用

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v9i4.38106