网膜素-1与脑梗死研究进展

颖 雷(浙江省衢州市人民医院神经内科，中国)

摘要

近年来，脂肪因子网膜素 -1 的临床和基础研究取得了很大进展。论文在国际文献基础上，对网膜素的结构元素和分布，以及其与肥胖、胰岛素抵抗、炎症、血管内皮功能、动脉粥样硬化、脑梗死等相关内容进行综述 , 希望能为脑梗死的预测和治疗提供新的视角。

关键词

网膜素 -1（Omentin-1）；脑梗死；动脉硬化；炎症

参考

陈竺.全国第三次死因回顾抽样调查报告[M].北京:中国协和医科大学出版社,2008:52-53.

刘鸣,张苏明,郝子龙.中国急性缺血性卒中诊治指南2010版的制定及解读[J].中华神经科杂志,2011(06):369-374.

Moreno Navarrete J M,Catalán V,Ortega F,et al.Circulating omentin concentration increases after weight loss［J］. Nutr Metab（Lond）,2010(07):27.

SAELY CH, LEIHERER A, MUENDLEIN A, etal. Plasma omentin significantly predicts cardiovascular events independently from the presence and extent of angiographically determined baseline coronary artery disease[J]. Atherosclerosis,2014(12):A1581.

Panagiotou G，Mu T．，Na B，et a1．Circulating irisin，omefitin-1，and lipoprotein subparticles in adults at higher cardiovascular riskl [J]．Metabolism，2014(10):1265-1271．

Yue J, Chen J, Wu Q, Liu X, Li M, Li Z, Gao Y. Serum levels of omentin-1 association with early diagnosis, lesion volume and severity of acute ischemic stroke. Cytokine,2018(111):518–522.

Xu T, Zuo P, Wang Y, Gao Z, Ke K. Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients. Clin Chem Lab Med,2018(56):350–355.

Yang RZ，Lee MJ，Hu H，eta1．Identification of omentin as a novel depot-specific adipokine in human adipose tissue：possible role in modulating insulin action[J]．Am J Physiol Endocrinol Metab,2006(06):1253—1261．

Poirier P，Giles TD，Bray GA，eta1．Obesity and cardiovascular disease：pathophysiology，evaluation，and effect of wetght loss[J]． Arterioscler Thromb Vasc Biol,2006(05):968-976．

ODonnell MJ, Xavier D, Liu L, etal. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study):a case-control study[J]. Lancet,2010(35):112-123.

Banh S,Klein P.Horbach T.eta1.Expression of neuropeptide Y, omentin and visfatin in visceral and subcutaneous adipose tissues in humans：relation to endocrine and clinical parameters[J]．Obes Facts,2010(04):245-251.

Koleva DI,Orbetzova MM,Atanassova PK.Adipose tissue hormones and appetite and body weight regmlators in insulin resistance[J].Folia Med(Plovdiv)，2013(01):25-32

Saremi A,Asghari M,Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men[J]. J Sports Sci,2010(09):993-998.

王光,王代第,杨方印.脑梗死患者的危险因素分析[J].中国实用神经疾病杂志,2009(09):42-43.

OhtaY,Takao Y,Harada K, etal. Metabolic syndrome is a risk factor for acute cerebral infarction in a younger elderly kurashiki population [J] .Journal of Stroke and Cerebrovascular Diseases,2010(03):1-9.

O’Donnell MJ,Xavier D, Liu L, etal.Risk factors for ischaemicand intracerebral haemorrhagic stroke in22 countries(the IN-TER STROKE study) ：a case-control study[J] .Lancet,2010(35):112-123.

蔡润策,魏丽,狄建忠,等.肥胖和2型糖尿病患者脂肪组织网膜素的 mRNA 表达[J].中华医学杂志,2009(06):381-384.

DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i3.3943