开放期刊系统

中西医局部外用药治疗糖尿病足机制研究进展

心苑 刘(中国人民解放军联勤保障部队第906医院,中国)

摘要

糖尿病足是糖尿病严重的慢性并发症之一,以足部溃疡、感染、微循环障碍及神经病变为特征,具有难愈合、易复发、高致残率等特点,给患者及医疗系统带来沉重负担。局部外用药因直接作用于创面、靶向性强、全身不良反应少等优势,成为糖尿病足治疗的核心手段。本文分析西医局部外用药与中医外用方药治疗糖尿病足的作用机制,总结中西医结合局部用药的协同效应及研究现状,为糖尿病足局部用药的临床优化应用及机制研究提供参考。

关键词

糖尿病足;局部外用药;中西医结合;作用机制;研究进展

全文:

PDF

参考

中华医学会糖尿病学分会.中国 2 型糖尿病防治指南 (2022 年版)[J]. 中华糖尿病杂志,2022,14 (04):367-488.

王辰,王建安.内科学 (第 9 版)[M]. 北京:人民卫生出版社,2018:736-740.

陈文阁,于游.中西医治疗糖尿病足研究进展 [J]. 临床医学进展,2025,15 (5):2092-2098.

李金岭,郭鹏程,宋伟.外用复方黄柏液涂剂辅助治疗糖尿病足患者的疗效观察 [J]. 世界中西医结合杂志,2023,18 (12):2422-2426.

刘晓宁.局部应用中药治疗糖尿病足溃疡的 Meta 分析 [J]. 中国医药指南,2017,15 (3):180-181.

陈观平,高晶晶,贾冬,等.功能性水凝胶敷料在糖尿病慢性伤口中的应用研究进展 [J]. 大连医科大学学报,2024, 46 (4): 346-351,356.

Thanigaimani S, Jin H, Ahmad U,et al. Comparative efficacy of growth factor therapy in healing diabetes-related foot ulcers: A network meta-analysis of randomized controlled trials[J]. Diabetes Metab Res Rev, 2023, 39(5): e3670.

Li Y, Wang H, Zhang L, et al. Traditional Chinese Medicine and Western Medicine in Promoting Diabetic Foot Ulcer Healing: Cellular and Molecular Mechanisms[J]. Journal of Biomechanics and Medicine in Biology, 2026, 1(1): 1-15.

Louisell AE, Niemiec SM, Zgheib C, et al. Macrophage polarization and diabetic wound healing[J]. Transl Res, 2021, 236: 109-116.

Huang YY, Lin CW, Cheng NC, et al. Effect of a novel macrophage regulating drug on wound healing in patients with diabetic foot ulcers: a randomized clinical trial[J]. JAMA Netw Open, 2021, 4(9): e2122607.

Kishta M S, Hafez A M, Hydara T, et al. The transforming role of wharton’s jelly mesenchymal stem cell-derived exosomes for diabetic foot ulcer healing: a randomized controlled clinical trial[J]. Stem Cell Research & Therapy, 2025, 16: 559.

杜明威,朱信霖,廖万清,等.中西医治疗糖尿病足溃疡的研究现状[J]. 2024,38(2):128-133.

Chen J, Liu S, Wu Y, et al. Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress[J]. Frontiers in Cell and Developmental Biology, 2025, 13: 1666646.

El-Wakeel A, El-Sayed A, El-Hassan M. A comparative study between the effect of topical insulin vs conventional betadine dressing on wound healing of diabetic foot ulcers[J]. Biomedical and Biopharmaceutical Research, 2025, 11(1): 1006-1012.

Zhang Q, Zhao X, Sun J, et al. Shengji ointment combined with bromelain promotes granulation of exposed tendons in diabetic foot ulcers: A multicenter, randomized, positive-controlled clinical trial[J]. PLoS One, 2025, 20(11): e011585806.

Al-Jahdali H, Al-Mazrou Y, Al-Rasheed K. Current Therapeutic Modalities for the Management of Chronic Diabetic Wounds of the Foot[J]. International Journal of Molecular Sciences, 2025, 26(12): 9937766.



DOI: http://dx.doi.org/10.12345/yzlcyxzz.v9i5.39836

Refbacks

  • 当前没有refback。
版权所有(c)2026 心苑 刘 Creative Commons License
此作品已接受知识共享署名-非商业性使用 4.0国际许可协议的许可。
  • :+65-62233778 QQ:2249355960 :contact@s-p.sg