二甲双胍与糖尿病患者乳酸酸中毒

志路 李(海南医学院第一临床学院，中国)
赛嘉 李(海南医学院第一临床学院，中国)
洪海 李(海南医学院第一临床学院，中国)
宇萱 王(海南医学院公共卫生学院，中国)
小敏 庄(海南医学院管理学院，中国)
冰心 许(海南医学院第一临床学院，中国)
莹婧 杜(海南医学院第一临床学院，中国)
代锋 周(海南医学院基础医学与生命科学学院，中国)

摘要

二甲双胍是临床上治疗糖尿病的基础药物，常用于治疗2型糖尿病（Type 2 Diabetes Mellitus ,T2DM），其效果在T2DM的临床治疗中得到充分验证。但在使用二甲双胍药物治疗T2DM过程中仍有一定机率出现相关性乳酸酸中毒的情况，且病死率较高，那么使用二甲双胍药物治疗是否是糖尿病患者乳酸酸中毒的直接危险因素？论文针对二甲双胍的降糖机制、与乳酸酸中毒的相关研究进行梳理，以进一步探究二甲双胍与糖尿病患者乳酸酸中毒的关系，为二甲双胍药物在T2DM的临床治疗当中提供帮助与参考依据。

关键词

二甲双胍；T2DM；相关性乳酸酸中毒

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i6.5077