维生素D代谢通路单核苷酸多态性与系统性红斑狼疮的关联性研究进展

赛嘉 李(海南医学院第一临床学院，中国)
志路 李(海南医学院第一临床学院，中国)
奕渔 蔡(海南医学院热带医学与检验医学院，中国)
冠陆 黎(海南医学院国际教育学院，中国)
小敏 庄(海南医学院管理学院，中国)
腾霄 褚(海南医学院第一临床学院，中国)
代锋 周(海南医学院基础医学与生命科学学院，中国)

摘要

维生素D是维持机体正常生理活动的必需维生素。大量研究表明，维生素D作为脂溶性维生素，除钙磷代谢经典效应外，在机体的免疫调节、抗炎症反应、细胞增殖等方面的作用日受到研究者的关注。系统性红斑狼疮（systemic lupus erythematosus,SLE）是一种是受环境、遗传等多种因素共同作用下导致多组织、多器官损害的特异性自身免疫性结缔组织病。在诸多因素中，维生素D代谢通路基因对于其发生发展起十分重要的调控作用。遗传多态性是个体差异和疾病发生发展的遗传基础，单核苷酸多态性是最常见的遗传变异。多篇文献表明，维生素D代谢通路基因单核苷酸多态性与SLE有相关联性。于是论文通过查阅相关文献，从基因层面出发，对维生素代谢通路基因单核苷酸多态性与SLE发生发展相关的研究进展进行归纳总结，为未来治疗提供新思路

关键词

维生素D代谢通路；单核苷酸多态性；系统性红斑狼疮

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i6.5079