四跨膜蛋白超家族CD82、CD151与恶性肿瘤

阳 张(内蒙古医科大学附属医院，中国)
新祥 吕(内蒙古医科大学附属医院，中国)

摘要

四跨膜蛋白超家族（TM4SF）是一类能跨膜连接蛋白，促进细胞间及细胞内信号转导，参与某些病毒的细胞识别和浸染的低分子量细胞膜糖蛋白，其广泛表达于皮肤、前列腺、子宫内膜及肺泡细胞等人体多种组织细胞中。其中，CD82与CD151是其家族的重要成员。TM4SF可与组织细胞表面其他蛋白形成复杂的复合物，进一步影响组织细胞的多种生物学功能。在许多研究中发现CD151、CD82与癌细胞的侵袭和转移以及转移抑制等作用有关，在皮肤恶性肿瘤中相关作用机制也在被逐渐发现。研究CD151、CD82与恶性肿瘤的关系，有助于明确恶性肿瘤的侵袭和转移机制，并对检测及确定恶性肿瘤早期诊断的标志物、合理估计肿瘤的侵袭及转移能力，制定完善的临床治疗计划，如何对肿瘤转移进行基因治疗等有重大意义。

关键词

CD82；CD151；四跨膜蛋白超家族；恶性肿瘤；皮肤恶性肿瘤

参考

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i6.5825