BRD4的分子机制与生理作用

银 梁(中国药科大学，中国)
焘 吴(中国药科大学，中国)

摘要

BRD4是BET蛋白家族的成员之一。它识别乙酰化的组蛋白和非组蛋白，参与众多的生理过程，因此它的不正常功能常导致多种疾病的发生发展。在这篇综述中，我们总结了BRD4在基因转录调节和其他细胞过程中的分子机制，以及这些机制在发育和转录记忆中的作用。此外我们还讨论了BRD4与疾病，尤其是癌症和病毒感染的关系。

关键词

BRD4；蛋白乙酰化；基因转录；发育；癌症；病毒感染　

参考

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DOI: http://dx.doi.org/10.26549/ajcm.v4i2.6679