非小细胞肺癌代谢重编程的研究进展

礼亮 杨(中国药科大学，中国)
煜新 周(中国药科大学，中国)
立彬 魏(中国药科大学，中国)

摘要

肺癌是全世界癌症死亡的主要原因。非小细胞肺癌(Non-Small Cell Lung Carcinoma， NSCLC)是肺癌中最常见的亚型，晚期NSCLC患者的预后仍然很差。考虑到新疗法的需要，人们对NSCLC的代谢进行了广泛研究，以确定其代谢特点，从而将其转化为新的抗代谢治疗方法。肺癌的代谢特性已经在体内得到了详细的描述，包括高葡萄糖和乳酸代谢以及其他高营养物质使用和线粒体途径的高异质性。论文阐述了近年来有关葡萄糖、脂肪酸和氨基酸代谢在NSCLC中的成果，为攻克NSCLC提供了新的思路。

关键词

非小细胞肺癌；代谢重编程；糖酵解；脂肪酸代谢；氨基酸代谢　

参考

Faubert B, Solmonson A, DeBerardinis RJ.Metabolic reprogramming and cancer progression[J]. Science,2020, 368:6487.

Camidge DR, Doebele RC, Kerr KM: Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC. Nat Rev Clin Oncol 2019, 16(6):341-355.

Gu NJ, Wu MZ, He L et al: HPV 16 E6/E7 up-regulate the expression of both HIF-1alpha and GLUT1 by inhibition of RRAD and activation of NF-kappaB in lung cancer cells. J Cancer 2019, 10(27):6903-6909.

Hall Z, Ament Z, Wilson CH. Myc Expression Drives Aberrant Lipid Metabolism in Lung Cancer[J]. Cancer Res,2016, 76(16):4608-4618.

Mayers JR, Torrence ME, Danai LV. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers[J]. Science, 2016, 353(6304):1161-1165.

Liu G, Summer R: Cellular Metabolism in Lung Health and Disease[J]. Annu Rev Physiol,2019, 81:403-428.

Giacomini I, Ragazzi E, Pasut G.The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance[J]. Int J Mol Sci,2020, 21(3):188-190.

Singh A, Happel C, Manna SK et al: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis. J Clin Invest 2013, 123(7):2921-2934.

Lebeau P, Byun JH, Yousof T.Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death. Toxicol Appl Pharmacol, 2018, 349:1-7.

Saliakoura M, Reynoso-Moreno I, Pozzato C.The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer[J]. Oncogene,2020, 39(14):2948-2960.

Galan-Cobo A, Sitthideatphaiboon P, Qu X.LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma[J]. Cancer Res,2019, 79(13):3251-3267.

Gwinn DM, Lee AG, Briones-Martin-Del-Campo M.Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase[J]. Cancer Cell,2018, 33(1):91-107+106.

Lin J, Lee JHJ, Paramasivam K. Induced-Decay of Glycine Decarboxylase Transcripts as an Anticancer Therapeutic Strategy for Non-Small-Cell Lung Carcinoma[J]. Mol Ther Nucleic Acids,2017, 9:263-273.

DOI: http://dx.doi.org/10.26549/ajcm.v4i2.6682