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非小细胞肺癌代谢重编程的研究进展

礼亮 杨(中国药科大学,中国)
煜新 周(中国药科大学,中国)
立彬 魏(中国药科大学,中国)

摘要

肺癌是全世界癌症死亡的主要原因。非小细胞肺癌(Non-Small Cell Lung Carcinoma, NSCLC)是肺癌中最常见的亚型,晚期NSCLC患者的预后仍然很差。考虑到新疗法的需要,人们对NSCLC的代谢进行了广泛研究,以确定其代谢特点,从而将其转化为新的抗代谢治疗方法。肺癌的代谢特性已经在体内得到了详细的描述,包括高葡萄糖和乳酸代谢以及其他高营养物质使用和线粒体途径的高异质性。论文阐述了近年来有关葡萄糖、脂肪酸和氨基酸代谢在NSCLC中的成果,为攻克NSCLC提供了新的思路。

关键词

非小细胞肺癌;代谢重编程;糖酵解;脂肪酸代谢;氨基酸代谢 

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DOI: http://dx.doi.org/10.26549/ajcm.v4i2.6682

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