HMGB1生物学功能及其研究进展

俊楠 侯(内蒙古医科大学，中国)
丽娜 刘(内蒙古自治区人民医院，中国)
燕 李(内蒙古自治区人民医院，中国)
佳林 王(内蒙古自治区人民医院，中国)
瑞芳 郭(内蒙古自治区人民医院，中国)

摘要

高迁移率族蛋白B1 ( HMGB1 )是哺乳动物细胞中高度保守的一种核蛋白，在细胞内部和细胞外具有组成细胞骨架蛋白，调节基因转录，诱导炎性反应，参与肿瘤细胞生殖分化及迁移，促进神经细胞生长，影响血管内皮细胞，影响免疫系统等重要的功能。因此在许多疾病中都发挥着重要的作用。

关键词

HMGB1；肿瘤；基因转录

参考

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DOI: http://dx.doi.org/10.26549/ajcm.v4i2.6683