长链非编码RNA SNHG3在乳腺癌组织中的表达及其预后作用

炳君 郭(重庆医科大学附属第一医院超声科，中国)
程 杨(重庆医科大学附属第一医院内分泌乳腺外科，中国)

摘要

目的：探讨SNHG3在乳腺癌组织中的表达及其潜在预后价值。方法：利用公共数据库研究SNHG3在乳腺癌中的作用。采用实时定量聚合酶链式反应（qRT-PCR）检测乳腺癌组织及其配对癌旁组织中SNHG3的表达水平，并比较两组之间的表达差异。采用卡方检验分析乳腺癌中SNHG3的表达水平与临床病理特征之间的相关性，随后进行Kaplan-Meier生存分析，并使用Cox回归模型进一步研究SNHG3的表达在乳腺癌中的预后价值。结果：在乳腺癌患者中，SNHG3在癌组织中表达水平较癌旁组织明显升高，且SNHG3的表达高低与肿瘤大小、淋巴结转移和TNM分期呈正相关。高表达组患者的无病生存期（disease-free survival，DFS）和总生存期（overall survival，OS）均短于低表达组，且SNHG3可能是乳腺癌患者DFS和OS的独立预后因素。结论：SNHG3在乳腺癌组织中表达升高，且与较大肿瘤体积、淋巴结转移和TNM分期晚有关，是乳腺癌患者的独立危险因素，可能成为乳腺癌患者预后标志物之一。

关键词

乳腺癌；SNHG3；生物标志物；预后

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v4i4.7079