开放期刊系统

肥胖对育龄女性生育能力影响的研究进展

花 李(内蒙古医科大学,中国)
金英 何(内蒙古自治区人民医院生殖医学中心,中国)
玉珍 马(内蒙古自治区人民医院生殖医学中心,中国)

摘要

肥胖严重影响着女性健康,尤其是对育龄女性的生育能力可能有一系列负面影响。育龄期的肥胖妇女大多表现为月经失调、排卵稀发和雄激素过多等。肥胖能够导致内分泌改变、改变代谢途径及其在靶器官的作用水平从而引起不孕,也是引起多囊卵巢综合征、高雄激素和代谢异常的关键因素。多囊卵巢综合征(以下简称PCOS)是不孕的主要原因之一,许多PCOS的女性也合并超重或肥胖。故通过减轻体重可改善性激素紊乱、调节内分泌,同时提高肥胖女性生育力。

关键词

肥胖;女性生育能力;多囊卵巢综合征;胰岛素抵抗;减重

全文:

PDF

参考

中国超重肥胖医学营养治疗专家共识编写委员会.超重/肥胖医学营养治疗专家共识(2016年版)[J].中国糖尿病杂志,2016,8(9):525-540.

Zhang X, Zhang M, Zhao Z, et al. Geographic variation in prevalence of adult obesity in china: Results from the 2013—2014 national chronic disease and risk factor surveillance[J]. Ann Intern Med, 2020,172(4):291-293.

Ramlau-Hansen CH, Thulstrup AM, Nohr EA, et al. Subfecundity in overweight and obese couples[J]. Hum Reprod, 2007,22(6):1634-1637.

Van Der Steeg JW , Steures P , Eijkemans MJ, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women[J]. Hum Reprod, 2008,23(2):324-328.

Talmor A, Dunphy B. Female obesity and infertility[J]. Best Pract Res Clin Obstet Gynaecol, 2015,29(4):498-506.

Escobar-Morreale HF. Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment[J]. Nat Rev Endocrinol, 2018,14(5):270-284.

Yildiz BO, Bozdag G, Yapici Z, et al. Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria[J].Hum Reprod, 2012,27(10):3067-3073.

Rachoń D, Teede H. Ovarian function and obesity–interrelation-ship, impact on women’s reproductive lifespan and treatment options[J]. Mol Cell Endocrinol, 2010,316(2):172-179.

Jungheim ES, Moley KH. Current knowledge of obesity’s effects in the pre and periconceptional periods and avenues for future research[J]. Obstet Gynecol, 2010,203(6):525-530.

Burt Solorzano CM, Helm KD, Patrie JT, et al. Increased adrenal androgens in overweight peripubertal girls [J]. Endocr Soc, 2017,1(5):

-552.

Dimopoulou C, Goulis DG, Corona G, et al. The complex association between metabolic syndrome and male hypogonadism [J]. Metabolism, 2018(86):61-68.

Broughton DE, Moley KH. Obesity and female infertility: Potential mediators of obesity’s impact[J]. Fertil Steril, 2017,107(4):840-847.

Kaye L, Sueldo C, Engmann L, et al. Survey as-sessing obesity policies for assisted reproductive technology in the United States[J]. Fertil Steril, 2016,105(3):703-706.

Zachariah M, Fleming R, Acharya U. Management of obese women in assisted conception units: A UK survey[J]. Hum Fertil (Camb), 2006,9(2):101-105.

Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy[J]. Hum Reprod, 2007,22(2):414-420.



DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i5.7733

Refbacks

  • 当前没有refback。
版权所有(c)2021 花 李, 金英 何, 玉珍 马 Creative Commons License
此作品已接受知识共享署名-非商业性使用 4.0国际许可协议的许可。
  • :+65-62233778 QQ:2249355960 :contact@s-p.sg