老年急性髓系白血病的治疗进展

亚莉 张(内蒙古医科大学，中国)
丽梅 李(内蒙古自治区人民医院血液科，中国)
阿荣 金(内蒙古自治区人民医院血液科，中国)

摘要

急性髓系白血病（AML）是一种以髓系低分化细胞不受控制的克隆增殖为特征的髓系疾病，是老年人最常见的白血病类型。其特点为起病急，病情进展迅速，影响大且预后较差。临床表现为出血、感染、贫血、代谢异常等情况。由于老年患者各项身体素质较差，与年轻患者相比，常规治疗方案老年人在耐受力及治疗效果上都表现的差强人意。幸运的是，近几年AML治疗进展发展迅速，出现了有许多新的有前途的治疗方案。论文在此简要总结老年人的治疗决策及经典治疗方案，重点讲述几个新获批准的药物，包括gemtuzumab、midostaurin、CPX-351、HMA、venetoclax、glasdegib、enasidenib和ivosidenib以及它们的特定适应症。

关键词

急性髓系白血病；老年患者；治疗方案；新型药物

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i6.7964