细胞焦亡在炎症性骨病中的研究进展

特 陈(南方医科大学南方医院创伤骨科，中国)
先荣 张(南方医科大学南方医院创伤骨科，中国)

摘要

大量患者受到炎症性骨病的困扰，目前对炎症性骨病的防治已取得初步效果，但在炎症环境下骨组织稳态改变研究仍需进一步展开，骨组织稳态的维持需要各种细胞参与，细胞在炎性环境可发生包括焦亡在内的炎性死亡。细胞焦亡是最新发现最具炎性特征的死亡方式，论文对有关细胞焦亡及其对炎症性骨病作用的相关研究进行综述。

关键词

细胞焦亡；炎症性骨病；炎症性骨丢失

参考

Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues[J]. Cell, 2011,147(4): 728-741.

D’ARCY M S. Cell death: a review of the major forms of apoptosis, necrosis and autophagy[J]. Cell Biol Int, 2019,43(6): 582-592.

WANG K, SUN Q, ZHONG X, et al. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis[J]. Cell, 2020,180(5): 941-955.

Boucher D, Monteleone M, Coll R C, et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity[J]. Exp Med, 2018,215(3): 827-840.

Kovacs S B, Miao E A. Gasdermins: Effectors of Pyroptosis[J].Trends Cell Biol, 2017,27(9): 673-684.

WANG Y, GAO W, SHI X, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin[J]. Nature, 2017,547(7661): 99-103.

Fritsch M, Günther S D, Schwarzer R, et al. Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis[J]. Nature, 2019,575(7784): 683-687.

Spel L, Martinon F. Inflammasomes contributing to inflammation in arthritis[J]. Immunol Rev, 2020,294(1): 48-62.

Son C N, Bang S Y, Kim J H, et al. Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout[J]. Korean Med Sci, 2013,28(9): 1289-1292.

ZHU X, ZHANG K, LU K, et al. Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis[J]. Ann Transl Med, 2019,7(8): 170.

LI Y, LING J, JIANG Q. Inflammasomes in Alveolar Bone Loss[J]. Front Immunol, 2021(12): 691013.

Charatcharoenwitthaya N, Khosla S, Atkinson E J, et al. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women[J]. J Bone Miner Res, 2007,22(5): 724-729.

Alippe Y, Wang C, Ricci B, et al. Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation[J]. Sci Rep, 2017,7(1): 6630.

Furman D, Chang J, Lartigue L, et al. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states[J]. Nat Med, 2017,23(2): 174-184.

Youm Y H, Grant R W, Mccabe L R, et al. Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging[J]. Cell Metab, 2013,18(4): 519-532.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i7.8422