雄激素性脱发的微针治疗进展

晶晶 吴(华北理工大学附属医院，中国)
琴月 刘(华北理工大学附属医院，中国)
丽洁 王(华北理工大学附属医院，中国)
洁 杨(华北理工大学附属医院，中国)

摘要

近年来微针技术发展迅速，已被广泛用于皮肤科疾病，包括雄激素性脱发和斑秃、痤疮瘢痕、烧伤瘢痕、黄褐斑等。虽然微针疗法在脱发中应用的研究数量有限，但它仍然是一种良好的治疗方式，目前还没有针对微针治疗雄激素性脱发的标准化方案。论文综述了近十年微针治疗雄激素性脱发的单一疗法或与其他疗法联合使用的情况。认识微针作为脱发治疗方式的优势与不足。

关键词

雄激素性脱发；脱发；微针；经皮胶原诱导

参考

Hou A , Cohen B , Haimovic A , et al. Microneedling: A Comprehensive Review[J]. Dermatologic Surgery Official Publication for American Society for Dermatologic Surgery,2016,43(3):321.

Vandervoort J, Ludwig A . Microneedles for Transdermal Drug Delivery: a Minireview[J]. Frontiers in Bioscience, 2008, 13(5):1711-1715.

Bonati L M, Epstein G K , Strugar T L. Microneedling in All Skin Types: A Review[J]. Journal of drugs in dermatology: JDD,2017,16(4):308-314.

Fernandes D, J D. Percutaneous collagen induction: An alternative to laser resurfacing[J]. Aesthetic Surg J,2002,22(3):307-309.

Vañó-Galván S, Camacho F. New Treatments for Hair Loss[J]. Actas Dermosifiliogr,2017,108(3):221-228.

Sfl A, Shs B, Sk A, et al. Transcutaneous Implantation of Valproic Acid-encapsulated Dissolving Microneedles Induces Hair Regrowth[J]. Biomaterials, 2018(167):69-79.

Seob K Y, Ho J K , Eun K J, et al. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model[J]. Annals of Dermatology,2016,28(5):586-592.

Verbaan FJ, Bal SM, Van Den Berg DJ, et al. Assembled Microneedle Arrays Enhance the Transport of Compounds Varying Over a Large Range of Molecular Weight Across Human Dermatomed Skin[J]. J Control Release,2007,117(2):238-245.

Schwarz M, Laaff H. A prospective Controlled Assessment of Microneedling with the Dermaroller Device[J]. Plastic & Reconstructive Surgery,2011,127(6):146.

Starace, Michela & Alessandrini, Aurora & Brandi, et al. Preliminary Results of the Use of Scalp Microneedling in Different Types of Alopecia[J]. Journal of Cosmetic Dermatology,2019(5):8-10.

Dhurat R, Sukesh M, Avhad G, et al. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: a Pilot Study[J]. Int J Trichology,2013,5(1):6-11.

Kumar MK, Inamadar AC, Palit A. A Randomized Controlled, Single-observer Blinded Study to Determine the Efficacy of Topical Minoxidil plus Microneedling versus Topical Minoxidil Alone in the Treatment of Androgenetic Alopecia[J]. J Cutan Aesthet Surg,2018,11(4):211-216.

鲍琳琳.微针联合5%米诺地尔酊外用治疗男性雄激素性脱发的临床观察及在相关信号通路中的分子机制研究[D].沈阳:中国医科大学,2018.

Nilforooshzadeh MA, Lotfi E, Heidari-Kharaji M, et al. Effective Combination Therapy with High Concentration of Minoxidil and Carboxygas in Resistant Androgenetic Alopecia: Report of Nine Cases[J]. J Cosmet Dermatol,2020,19(11):2953-2957.

Gupta AK, Carviel J. A Mechanistic Model of Platelet-rich Plasma Treatment for Androgenetic Alopecia[J]. Dermatol Surg,2016,42(12):1335-1339.

Jha AK, Vinay K, Zeeshan M,et al. Platelet-rich Plasma and Microneedling Improves Hair Growth in Patients Ofandrogenetic Alopecia When Used as an Adjuvant to Minoxidil[J]. J Cosmet Dermatol,2019(28):38-40.

Farid C I, Abdelmaksoud R A. Platelet-rich Plasma Microneedling Versus 5% Topical Minoxidil in the Treatment of Patterned Hair Loss[J]. Journal of the Egyptian Women’s Dermatologic Society,2016,13(1):78-80.

Sasaki GH. Micro-needling Depth Penetration, Presence of Pigment Particles, and Fluorescein-Stained Platelets: Clinical Usage for Aesthetic Concerns[J]. Aesthet Surg J,2017,37(1):71-83.

Lee YB, Eun YS, Lee JH, et al. Effects of Topical Application of Growth Factors Followed by Microneedle Therapy in Women With Female Pattern Hair Loss: a Pilot Study[J]. J Dermatol,2013,40(1):81-83.

Nilforooshzadeh MA, Lotfi E, Heidari-Kharaji M, et al. Effective Combination Therapy with High Concentration of Minoxidil and Carboxygas in Resistant Androgenetic Alopecia: Report of Nine Cases[J]. J Cosmet Dermatol,2020,19(11):2953-2957.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i10.9065