肾癌作为一种代谢性疾病的研究进展

磊 祝(内蒙古医科大学，中国)
志中 云(内蒙古自治区人民医院泌尿外科，中国)
建坤 乔(内蒙古自治区人民医院泌尿外科，中国)
仁 莫(内蒙古自治区人民医院泌尿外科，中国)
治威 刘(内蒙古自治区人民医院泌尿外科，中国)
可为 马(内蒙古自治区人民医院泌尿外科，中国)

摘要

肾癌作为泌尿系的常见肿瘤，早期患者往往缺乏临床表现。当患者出现明显的“肾癌三联征”时，往往提示肾癌已进入晚期。将肾癌看作一种代谢性疾病，通过最新提出的代谢组学的方法，有望找到早期肾癌肿瘤标志物，以找到肾癌更有效的检查及治疗方法。论文针对肾癌作为一种代谢性疾病的研究进展进行综述。

关键词

肾细胞癌；代谢组学；肿瘤标志物；靶向治疗；实时成像

参考

Linehan W M, Walther M M, Zbar B. The genetic basis of cancer of the kidney[J].Urol, 2003(170):2163-2172.

Wettersten H I, Hakimi A A, Morin D, et al. Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis[J].Cancer Res,2015,75(12):2541-2552.

Leuthold P, Schaeffeler E, Winter S, et al. Comprehensive metabolomic and lipidomic profiling of human kidney tissue: a platform comparison[J].Proteome Res,2017,16(2):933-944.

Yoon C Y, Shim Y J, Kim E H, et al. Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase[J]. International journal of cancer,2007(120):897-905.

Abu Aboud O, Wettersten H I, Weiss R H. Inhibition of PPAR-alpha induces cell cycle arrest and apoptosis and synergizes with glycolysis inhibition in kidney cancer cells[J].PLoSOne, 2013(8):71115.

Wilhelm S M, Carter C, Tang L, et al. BAY 43–9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis[J].Cancer Res, 2004(19):7099-7109.

Ballatori N, Krance S M, Notenboom S, et al. Glutathione dysregulation and the etiology and progression of human diseases[J].Biol Chem,2009(390):191-214.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i10.9100