Articles

中医药抗三阴性乳腺癌研究现状

Abstract

三阴性乳腺癌(triple-negative breast cancer,TNBC)(TNBC)是乳腺癌中侵袭性最强、预后最差的分子亚型,因缺乏雌激素受体、孕激素受体和HER2(human epidermal growth factor receptor 2,HER2)靶点而无法从内分泌治疗或靶向治疗中获益,化疗仍是其主要治疗手段,但耐药率高、毒副作用显著。近年来,中医药在TNBC辅助治疗中的研究逐渐增多,涵盖活性成分的分子机制探索和临床中西医结合方案。本文基于“机制 - -方法 - -证据 - -转化”四个维度,在常规化疗的基础上归纳了中药有效成分干预 TNBC 相关通路的研究现状及网络生物学、多组学整合策略的方法论模式,总结了中医药在 TNBC 中作为辅助手段的循证医学证据水平及其存在的问题,最后针对上述不足提出了展望性建议。

Keywords

三阴性乳腺癌;中医药;信号通路;网络药理学;免疫微环境;中西医结合

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