Evaluation of the Value of Multidimensional Gastric Cancer Marker Combined Detection in Early Diagnosis

Chengbin Guo(Henan Massage Vocational College)

Abstract

Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, largely due to late diagnosis and poor prognosis. Early detection significantly improves survival rates, yet current diagnostic methods lack sufficient sensitivity and specificity, especially for early-stage disease. This study evaluates the diagnostic value of combined detection of multiple gastric cancer markers, including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 72-4 (CA72-4), to improve early diagnosis accuracy. A cohort of 300 patients, comprising early-stage gastric cancer patients and healthy controls, was analyzed using enzyme-linked immunosorbent assay (ELISA) techniques for individual and combined marker levels. Statistical analyses, including receiver operating characteristic (ROC) curves and logistic regression, assessed the diagnostic performance of the markers individually and in combination. Results indicate that combined marker detection significantly enhances sensitivity (up to 88%) and specificity (up to 85%) compared to single markers. This multidimensional approach holds promise for clinical application in screening and early diagnosis of gastric cancer, potentially leading to improved patient outcomes.

Keywords

Gastric cancer; Early diagnosis; Tumor markers; Combined detection; Multidimensional markers

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DOI: http://dx.doi.org/10.26549/jor.v6i1.26761